αII-Spectrin Regulates Invadosome Stability and Extracellular Matrix Degradation

αII-Spectrin Regulates Invadosome Stability and Extracellular Matrix Degradation

Invadosomes are actin-rich adhesion structures involved in tissue invasion and extracellular matrix (ECM) remodelling. αII-Spectrin, an ubiquitous scaffolding component of the membrane skeleton and a partner of actin regulators (ABI1, VASP and WASL), accumulates highly and specifically in the invadosomes of multiple cell types, such as mouse embryonic fibroblasts (MEFs) expressing SrcY527F, the...

The matrix corroded: podosomes and invadopodia in extracellular matrix degradation.

Podosomes and invadopodia are unique actin-rich adhesions that establish close contact to the substratum but can also degrade components of the extracellular matrix. Accordingly, matrix degradation localized at podosomes or invadopodia is thought to contribute to cellular invasiveness in physiological and pathological situations. Cell types that form podosomes include monocytic, endothelial and...

T Cell Control of Extracellular Matrix Degradation

Matrix metalloproteinases (MMP) are members of an enzyme family the extent of whose involvement in physiological and pathological situations is just beginning to be appreciated. A case in point is the vast array of normal and exacerbated immunological responses involving T cell recruitment to a particular site in the organism through the extracellular matrix (ECM). In order to penetrate and mig...

Cell organization, growth, and neural and cardiac development require αII-spectrin.

Spectrin α2 (αII-spectrin) is a scaffolding protein encoded by the Spna2 gene and constitutively expressed in most tissues. Exon trapping of Spna2 in C57BL/6 mice allowed targeted disruption of αII-spectrin. Heterozygous animals displayed no phenotype by 2 years of age. Homozygous deletion of Spna2 was embryonic lethal at embryonic day 12.5 to 16.5 with retarded intrauterine growth, and craniof...

Extracellular Matrix Heparan Sulfate Macrophages Regulates Degradation of Cell Surface Localization of Heparanase on